I use a range of laboratory tests to help identify how the body systems are functioning. Tests include: hair mineral analysis, blood sampling, urine and stool analysis to ascertain a current picture of health, any existing vitamin and mineral deficiencies, parasitic infections, or heavy metal levels within the body. I offer a full range of testing, please see the complete list below.
Living in the 21st century can be a very stressful existence. We’re exposed to more and more environmental stress and pollution, we have stress related to work and exams and even some of the food that we eat can be stress inducing. When we are exposed to stress our adrenal glands produce cortisol to help the body cope. If we are too stressed our adrenal glands start to fatigue and cant produce enough cortisol and we end up entering the vicious circle of stress related illnesses.
The way we produce cortisol is different for every individual that’s why most adrenal testing procedures monitor cortisol levels at different points of the day. The test gives an indication of how our body is coping with stress.
This test includes the measurement of oestradiol and progesterone from a single saliva sample. It is recommended for post-menopausal women, those taking hormone supplementation, or as an economical means of assessing luteal-phase hormone levels in pre-menopausal women.
This unique test measures the ratio of arachidonic acid (AA) to eicosapentaenoic acid (EPA) in plasma. This ratio of the principle omega-3 and omega-6 fatty acids is a measure of the body’s eicosanoid balance. Balancing the eicosanoids in the body is an excellent way for managing heart disease and other chronic and inflammatory processes.
Recently, a great deal of interest has been paid to the ratio of the fatty acids arachidonic acid (AA) to eicosapentaenoic acid (EPA). According to Dr. Barry Sears, author of Toxic Fat: When Good Fat Turns Bad, a lower AA/EPA ratio indicates a better balance of “good” and “bad” eicosanoids in your body. An AA/EPA ratio of less than 3 but not less than 1.5 is considered to be ideal. It is no longer considered “well” to have a ratio greater than 10. Anything exceeding 15 means a high level of inflammation in the blood (Toxic Fat Syndrome) and requires immediate dietary attention.
0240 – AA/EPA Ratio
As the principal endogenous inhibitor of nitric oxide synthase,ADMA (asymmetric dimethylarginine), regulates rates of nitric oxide (NO) formation. Nitric oxide acts as a signal molecule in the nervous system, as a weapon against infections, as a regulator of blood pressure, and as a gate keeper of blood flow to the organs. Elevated ADMA has been associated with various cardiovascular risk factors, renal failure, and erectile dysfunction. Factors contributing to elevated ADMA include increased oxidative challenge and folic acid insufficiency.
Because independent studies have shown that:
0014 – ADMA Profile
LC/MS-MS
Adrenal evaluation is commonly considered for patients with fatigue and a host of other complaints resulting from a history of chronic psychological or physiological stress. However adrenal evaluation is also vital for treating patients with hypothyroidism, due to the close interaction of these endocrinal systems. Urinary T3 levels are a sensitive measure of the active thryoid hormone which can give an accurate reflection of overall thyroid hormone levels. To help evaluate these intricately-linked areas, we have developed the Adrenal-Thyroid Profile. This consists of the Adrenal Stress Profile, (salivary cortisol and DHEA), as well as urinary T3 levels.
An increased cortisol level, a decreased DHEA-S level, or a decrease in the DHEA-S cortisol ratio is an indication of a chronically stressful physical or mental condition.
Stress is a major underlying cause of many chronic illnesses, from Chronic Fatigue Syndrome to food and environmental allergy. A stressful lifestyle can lead to consistently high levels of cortisol and low levels of DHEA (dehydoepiandosterone), which can be damaging to the brain and other tissues. Cortisol elevation also impacts immune responses, such as secretory IgA (sIgA) and antigliadin antibody (AGA) production. The Adrenal Stress Plus Profile is a measure of an individual’s response to stress. It is also an important tool for pointing to adrenal imbalances that may be impacting a patient’s health.
The adrenocortical hormones, cortisol and DHEA, are steroids that affect carbohydrate, protein, and lipid metabolism. They also serve as modulators of thyroid function and help the body manage stress. When levels of DHEA and cortisol change, it may indicate significant variations in adrenal function that can impact an individual’s energy levels, emotions, and even disease resistance.
Secretion of cortisol, regulated by the sleep-wake cycle, is characterized by a steep increase in the early morning, followed by a gradual tapering off until late evening. Stress causes elevated cortisol levels, which continue as long as the stressor is present. Stress also overrides negative feedback of cortisol in the Hypothalamus-Pituitary-Adrenocortex (HPA) axis. Prolonged stress, causing increased secretion of cortisol, may over time lead to hypertrophy of the adrenal cortex.
Among other functions, DHEA serves as a metabolic intermediate in the pathway for synthesis of testosterone, estrone, and estradiol in the adrenal glands, ovaries, and testes. Since DHEA in plasma has a very short half-life, most of circulating DHEA is in the sulfate form (DHEA-S). DHEA-S provides a ready source of DHEA for the production of estrogens and androgens.
The Adrenal Stress Profiles from Genova Diagnostics use a non-invasive salivary procedure to monitor the activity of the adrenal cortex and its ability to react to stress. The procedure monitors the circadian variation of cortisol and DHEA-S levels. An increased cortisol level, a decreased DHEA-S level, or a decrease in the DHEA-S/cortisol ratio is an indication of a chronically stressful physical or mental condition.
Adrenal Stress Plus Profile features:
The Adrenal Stress Plus Profile also measures sIgA and AGA. During a high stress situation, levels of sIgA decrease. Secretory IgA protects the gut from pathogenic material. Chronic cortisol elevation may be associated with high antigliadin antibodies (gliadin is a protein component found in wheat) due to intestinal hyperpermeability.
When the Adrenal Stress Profile indicates an inappropriate hormonal stress response, it is necessary to consider stress reduction through diet and lifestyle modification, and nutritional supplementation to support adrenal gland activity and enhance the restoration of the physical barrier in the gut.
0043 – Adrenal Stress Plus (sIgA & Antigliadin Antibody)
This saliva test can detect imbalances in the daily circadian secretions of the stress hormones cortisol and DHEA. Imbalances in these hormones can indicate an inappropriate response that can negatively impact energy levels, emotions, and many other health complaints. These include anxiety, chronic inflammatory conditions, allergies, chronic fatigue syndrome, insomnia, depression, migraines, headaches, recurrent infections, menstrual difficulties and infertility.
The IgG4 Food Antibodies – Bloodspot 30™ is a blood spot test that measures the total IgG levels that react to common food antigens. The test kit is simple enough for the patient to use at home.
From a simple finger stick, the Bloodspot IgG4 Food Antibodies Profile offers a non-invasive alternative to a blood draw in determining IgG food reactions. Responses to 30 different foods are tested, and responses are categorized by severity from borderline to mild, moderate, or severe on the report.
IgG4 antibodies are associated with non-atopic or “delayed” food reactions that can worsen or contribute to many health conditions. Food sensitivities can occur at any age, triggering a wide range of symptoms. The Bloodspot IgG4 Food Antibody Profilemeasures levels of IgG4 antibodies specific to 30 commonly offending foods clearly identifying foods causing patient reactions. Testing aids the clinician in the specific dietary change that is needed, helping to achieve positive outcomes sooner, even when combined with elimination or provocation testing.
0076 – IgG4 Food Antibodies – Bloodspot 30
Method: ELISA
The Celiac Profile – Serum – measures IgA-tTG, Serum IgA, and IgA-AGA. When IgA-tTG and IgA-AGA are positive, there is a high degree of certainty the patient has celiac disease. When IgA-tTG is positive with normal IgA-AGA, the patient may have celiac disease, but may have been following a gluten-free diet, reducing their IgA-AGA. Individuals with moderate to strong positives should follow up with a biopsy.
It is estimated that more than 2 million people in the United States alone have celiac disease.1 Celiac disease is an autoimmune response to gluten. Inherited factors make some individuals sensitive to a protein called gliadin, which is a part of the total protein or gluten found in grains such as wheat, rye, and barley. When people with celiac disease ingest gluten, their immune system responds by damaging their intestinal villi – the tiny, fingerlike protrusions lining the small intestine. Villi normally allow nutrients from food to be absorbed through the walls of the small intestine into the bloodstream. Damaged villi can lead to long-term complications from impaired absorption such as malnutrition, anemia, osteoporosis, and miscarriage, among other problems.
0078 – Celiac Profile
Method: ELISA and Immunoturbidometric assay
1Westberg, D.P., et al., New Strategies for diagnosis and management of celiac disease. J Am Osteopath Assoc, 2006. 18(1):p.145-51.
2Kumar V, Celiac disease and immunoglobulin a deficiency: how effective are the serological methods of diagnosis?
The Allergix IgG4 antibody is related to “delayed” or non-atopic food reactions that exacerbate or contribute to many different health problems.
An IgG4 response to food is actually more common than the IgE response, which causes an immediate reaction. These reactions are more difficult to notice since they can occur hours or even days after consumption of an offending food. In some cases, a person’s reaction to a food may occur several days after eating the offending food and the link between the food and their symptoms may not be connected. These “hidden” food allergies are caused by increasing blood levels of IgG4 antibodies in reaction to specific foods. This profile measures the IgG4 levels in serum that react to 90 different foods, including commonly eaten foods such as corn, milk, egg, and wheat. A food reaction patient guide is provided with each test result.
0075 – IgG4 Food Antibodies 90 Antigens
Method: ELISA
In addition to pinpointing problems in amino acid absorption and determining essential amino acid imbalances, the plasma amino acid 40 test includes evaluation of limiting, branched chain, and essential and non-essential amino acids. It also identifies several functional categories, such as neuroendocrine, vascular, collagen status and detoxification, along with five calculated ratios, and identifies vitamin and mineral insufficiencies.
Fasting plasma levels represent a homeostatic balance between supply and utilization of amino acids making this specimen option ideal for repeated assessments to monitor progress of treatment. Collecting a fasting plasma specimen from a patient removes recent dietary intake effects. The following factors can effect changes over time in plasma:
Amino acids, known as the “building blocks” of proteins, are found in every tissue of the body. They play a major role in nearly every chemical process that affects both physical and mental function including the formation of ligaments, tendons, bones, and antibodies, as well as regulation of enzymes and blood transport proteins. Twenty different amino acids are used to synthesize proteins.
The human body can synthesize all of the amino acids necessary to build proteins except for ten called the “essential amino acids”. These ten must be included in the diet or supplemented to be in adequate supplies. Failure to obtain enough of even 1 of the 10 essential amino acids has serious health implications and can result in degradation of the body’s proteins. Muscle and other protein structures may be dismantled to obtain the one amino acid that is needed.
0010 – Amino Acids – 40 analytes
Reversed Phase UHPLC Method
This test quantifies levels of circulating amino acids and their metabolites, and evaluates essential and non-essential amino acid nutrient status in the blood. It also can indicate functional deficiencies of a number of mineral and vitamin co-factors. This is an ideal test for patients with suspected inadequate protein utilization and other metabolic disorders including arthritis and depression.
This test measures all essential, non-essential and various metabolic products of amino acids as found in urine. This test can help to identify protein adequacy, gastrointestinal dysfunctions, protein intolerance, and disorders of metabolism. It can also assess vitamin and mineral deficiencies.
The Anaemia Profile measures blood levels of three important nutrients, which are often implicated in anaemia. These include folic acid, vitamin B12 and iron levels (measured in the form of ferritin).
The Bloodspot Amino Acid Profile can illuminate problems in amino acid absorption by determining essential amino acid imbalances from a simple finger stick. This profile is a great option for clinicians unable to draw blood and easy enough for the patient to collect in the comfort of their own home. A formula for a customized amino acid blend is also provided with every test result for individually formulated treatment.
This profile is available testing 11 analytes or 20 analytes. Please click on the ‘Clinician Info’ tab for a complete listing of analytes to see which profile is the best option for you.
Amino acids, known as the “building blocks” of proteins, are found in every tissue of the body. They play a major role in nearly every chemical process that affects both physical and mental function including the formation of ligaments, tendons, bones, as well as antibodies and regulation of enzymes and blood transport proteins. Twenty different amino acids are used to synthesize proteins.
With just a simple finger stick, these easy-to-use blood spot tests offer a non-invasive alternative to a blood draw in determining amino acid status.
0013 – Amino Acids – 11 analytes
HPLC
The Bloodspot Amino Acid Profile can illuminate problems in amino acid absorption by determining essential amino acid imbalances from a simple finger stick. This profile is a great option for clinicians unable to draw blood and easy enough for the patient to collect in the comfort of their own home. A formula for a customized amino acid blend is also provided with every test result for individually formulated treatment.
This profile is available testing 11 analytes or 20 analytes. Please click on the ‘Clinician Info’ tab for a complete listing of analytes to see which profile is the best option for you.
Amino acids, known as the “building blocks” of proteins, are found in every tissue of the body. They play a major role in nearly every chemical process that affects both physical and mental function including the formation of ligaments, tendons, bones, as well as antibodies and regulation of enzymes and blood transport proteins. Twenty different amino acids are used to synthesize proteins.
With just a simple finger stick, these easy-to-use blood spot tests offer a non-invasive alternative to a blood draw in determining amino acid status.
0113 – Amino Acids – 20 analytes
HPLC
From a simple finger stick it measures key omega-3 and omega-6 fatty acids and calculates key indicators to establish your optimal balance. Trans fatty acids the “bad” oils in processed foods are also measured.
0241 – Bloodspot Fatty Acid Profile*
GC/MS
Polyunsaturated Omega-3
Polyunsaturated Omega-6
Trans
Accelerated bone loss affects more than 44 million Americans 50 years of age and older. 80% of them are women. But men, younger women, and otherwise healthy, active individuals can also experience the dangerous thinning and weakening of bones associated with osteoporosis. The Bone Resorption Assay can not only identify individuals at risk, but also monitor the effect of your therapeutic interventions.
Bone is a very active tissue, undergoing constant “remodeling,” a process of both formation and resorption. Net loss of bone mass occurs when the resorption rate exceeds the rate of formation of new bone. The rate of bone loss is highly variable from one individual to another. Since the bone formation process is difficult to assess, it is important to identify both men and women with rapid bone resorption. These individuals are at greatest risk for osteoporosis and will benefit most from therapeutic intervention.
The protein matrix of bone upon which the mineral structure is accumulated consists of Type I collagen. Type I bone collagen contains unique cross-linked protein structures that give greater stability. Active bone resorption requires a breakdown of this protein structure; the peptide fragments from this breakdown are excreted in urine. Since bone resorption is a relatively constant process, the amount of specific peptides found in the urine provides an accurate measure of the rate of bone resorption.
The Bone Resorption Assay measures the deoxypyridinolinefragment of Type I collagen breakdown from a single urine specimen. This is the fragment that contains the cross-linking point and has been demonstrated to be more specific to bone resorption than breakdown fragments measured in some earlier assays.
Serial bone scans are costly and do not indicate present bone activity. Also, they can only detect changes in bone density over long periods of time, often up to twelve months. The Bone Resorption Assay detects biochemical markers which reflect present remodeling activity. The relatively low cost of this assay makes it a cost-effective tool to routinely monitor bone resorption rates and the effectiveness of therapy. Repeated measurements every six to twelve weeks will monitor the effectiveness of your therapeutic interventions and allow timely adjustments.
0018 – Bone Resorption Assay
This test requires a single urine sample to measure pyridinium crosslinks and deoxypyridinoline, useful in identifying current rate of bone loss and efficacy of bone support therapies.
This test evaluates digestion and absorption, bacterial balance and metabolism, yeast and immune status for patients with irritable bowel syndrome, indigestion, malabsorption, and other GI-related problems. Additionally, Genova offers a parasitology component with the CDSA that evaluates for parasites using microscopic examination and EIA testing. This must be ordered as the CDSAP.
The CDSA 2.0 offers the most advanced non-invasive evaluation of digestion, absorption, gut flora, and the colonic environment. This profile is indicated for all chronic GI problems, for acute bowel pattern changes, and for many systemic diseases and provides a sensitivity panel for treating pathogenic flora. Additionally, parasites can be added but must be ordered as the CDSA2.0+P.
This test evaluates digestion, absorption, gut flora, and the colonic environment, and evaluates for parasites using microscopic examination and EIA testing. The profile is indicated for all chronic GI problems, for acute bowel pattern changes, and for many systemic diseases and provides a sensitivity panel for treating pathogenic flora.
The CDSA 2.0 offers the most advanced non-invasive evaluation of digestion, absorption, gut flora, and the colonic environment. This profile is indicated for all chronic GI problems, for acute bowel pattern changes, and for many systemic diseases and provides a sensitivity panel for treating pathogenic flora. The addition of Parasitology testing will also indicate whether there are any current parasitic infections.
This profile analyses blood and utilises NMR fractionation technology for state-of-the-art lipid markers and independent risk factors that illuminate the clinical complexity of cardiovascular disease (CVD), as well as a patient’s genomic predisposition to cardiovascular diseases. Together, these markers provide a thorough assessment of cardiovascular health status, revealing the biochemical environment and cardiogenomic risk associated with inflammation, lipid deposits, endothelial dysfunction, and clotting factors underlying cardiovascular disease.
This profile analyses blood and utilises NMR fractionation technology for state-of-the-art lipid markers and independent risk factors that illuminate the clinical complexity of cardiovascular disease (CVD). Together, these markers provide a thorough assessment of cardiovascular health status, revealing the biochemical environment associated with inflammation, lipid deposits, endothelial dysfunction, and clotting factors underlying cardiovascular disease.
Calprotectin is a highly-sensitive clinical biomarker for GI-specific inflammation. The United States Food and Drug Administration (FDA) has approved this non-invasive test as a way to differentiate Inflammatory Bowel Disease (IBD) from Irritable Bowel Syndrome (IBS) as well as also identifying other types of intestinal inflammation.
Candida is a yeast that is part of our digestive flora, however in some individuals the natural balance of the gut is disrupted leading to a pathogenic form of the organism. This results in many symptoms ranging from fatigue, bloating, diarrhoea/constipation, muscle aches and headaches, to name but a few. This test is used not only for detecting the presence of the infection but also as an indicator of the stage of the condition.
Candida is a yeast that is part of our digestive flora, however in some individuals the natural balance of the gut is disrupted leading to a pathogenic form of the organism. This results in many symptoms ranging from fatigue, bloating, diarrhoea/constipation, muscle aches and headaches, to name but a few. This test is used not only for detecting the presence of the infection but also as an indicator of the stage of the condition.
The Cardio/ION Profile is a combination of nutritional analyses that measures levels of fatty acids, amino acids, vitamins, minerals, antioxidants, organic acids, and risk factors for cardiovascular disease (CVD).
One in 3 adults has some form of cardiovascular disease2. An evaluation of standard lipid markers does not provide optimal assessment of risk.
The Cardio/ION identifies key nutritionally modifiable risk factors for CVD, including:
The Cardio ION Profile identifies critical CVD risk factors, including:
The Cardio ION Profile can also guide your treatment of many other conditions, including:
0290 – Cardio ION Health Profile
0068 – Chemistries
0290: LC/MS-MS, HPLC, UPLC, ICP/MS, GC/MS, Spectrophotometry,
Chemiluminescence, EIA
0068: Spectrophotometry, Automated Chemistry
1 Excerpt from Total Wellness, Sept. 2006 by Sherry Rogers, MD
2 N Hanes 1999-02, CDC/HCHS (American Heart Association)
This test evaluates genetic variations, called single nucleotide polymorphisms (SNPs), in genes that modulate blood pressure regulation, lipid balance, nutrient metabolism, inflammation, and oxidative stress.
This test combines the Adrenal Stress Profile and Metabolic Analysis tests to provide a comprehensive analysis of various factors that may be implicated in chronic fatigue and other related conditions.
Serum levels of the fat-soluble vitamins A and E, beta-carotene, and coenzyme Q10 are measures of total body status of these antioxidant nutrients.
Coenzyme Q10 (CoQ10) is produced by the human body and is necessary for the basic functioning of cells. CoQ10 levels are reported to decrease with age and to be low in individuals with certain chronic diseases. Some prescription drugs may also lower CoQ10 levels.
CoQ10 is essential for production of cell energy in the cell membrane or mitochondria. Using cholesterol lowering drugs, such as statins, can interfere with CoQ10 production, compromising cellular energy production. High performance athletes are candidates for testing CoQ10, as well as individuals that appear to have mitochondrial dysfunction, neurological or skeletal muscle disorders. Cases of genetic inability to produce adequate CoQ10 have been identified and treated successfully. Measuring both direct and indirect biomarkers of CoQ10 sufficiency in order to appropriately diagnose and treat individuals, and monitor CoQ10 administration, can markedly improve outcomes and prevent mitochondrial-related disease.
Genova Diagnostic profiles enable both direct and functional measurement of CoQ10 adequacy for diagnosis, treatment and follow-up. To further assess your need for CoQ10, a Lipid Peroxides Profile may also be performed.
0033 – Coenzyme Q10 Plus Vitamins
UPLC
Coeliac disease, also called coeliac sprue or gluten sensitivity enteropathy, is caused by an inability to properly digest foods containing gluten. Gluten is found in many grains including wheat, oats, rye, barley and spelt. The gliadin fraction is believed to be the problem. Coeliac disease is chronic, has a genetic component and may affect several family members. This is a life-long condition in which the ingestion of the gluten component of wheat and related cereals leads to damage to the intestinal lining, skin reactions or the nervous system.
Complete Hormones is the most comprehensive urinary hormone metabolism evaluation designed to assist in the prevention and treatment of hormone-related symptoms and conditions. This provides clues about menstrual irregularities, infertility, menopause, fatigue, breast cancer, and osteoporosis.
This test analyses key urinary markers from an overnight urine collection, providing insights into a wide range of disorders, from reduced libido and muscle mass to cardiovascular disease.
The Comprehensive Adrenal Stress Profile comprises of the standard Adrenal Stress Profile (which assesses cortisol and DHEA levels) and Secretory IgA (SIgA). Imbalances of cortisol, DHEA and SIgA can lead to the most common health complaints of the 21st century. Both excesses and deficiencies of DHEA and cortisol have been implicated in the aetiology of various illnesses and immune suppression.
A comprehensive evaluation of cardiovascular risk, measuring various important markers such as cholesterol, triglycerides, and homocysteine, as well as key inflammatory markers. This unique test combines both traditional and cutting-edge indicators of cardiovascular health that can often be corrected with nutritional intervention.
This test measures RBC intracellular concentrations of toxic elements and nutrient elements. This is an ideal test for patients suspected of recent toxic element exposure and for evaluation of intracellular mineral nutrient status.
This test measures urinary excretion of nutrient elements and toxic metals, including “classic” toxic metals such as lead, mercury, and arsenic. This is an ideal test for patients suspected of toxic element exposure as well as potential nutrient mineral wasting.
This comprehensive analysis combines the FACTest™, IgE Food Panel test and the Coeliac marker tTgA. Please see individual test Pages for further information.
This test evaluates stool for presence of parasites and levels of beneficial flora, imbalanced flora, pathogenic bacteria, and yeast. This is an ideal test for patients with changes in bowel pattern, especially for those who have been travelling abroad. Sensitivity panels comprising commonly used pharmaceutical and natural antimicrobials are tested against bacterial/ yeast cultures to help identify the most efficient way of addressing imbalances.
The Cortisol Awakening Response (CAR) test is a salivary assay available to assess adrenal dysfunction. The CAR test involves measuring five separate salivary samples over an hour after waking, and has been extensively researched and validated as a means of analysing hypothalamic-pituitary-adrenocortical (HPA) axis activity.
This single saliva sample measures DHEA levels, a stress hormone that decreases with age and can affect all Areas of health and wellbeing. It also allows for monitoring of DHEA supplementation, which should be carefully monitored.
This test evaluates SNPs associated with increased risk of impaired detoxification capacity especially when exposed to environmental toxins. It also identifies individuals potentially susceptible to adverse drug reactions.
This test evaluates the level of red cell membrane fatty acids, imbalances of which significantly affect inflammatory and other disorders. By knowing the various fatty acid levels, one can re-establish a balance using nutritional intervention.
This test provides a focused overview of oestrogen balance in both pre- and post-menopausal women, using a single urine sample to evaluate dynamics of sex steroid metabolism that can profoundly affect a woman’s health throughout her lifetime.
This test evaluates genetic variations, called single nucleotide polymorphisms (SNPs), in genes that modulate oestrogen metabolism, coagulation, cardiovascular disease, and osteoporosis.
The Estronex Profile measures six important estrogen metabolites and their ratios to help women, and even men, assess whether he or she is at risk of developing estrogen sensitive cancers.
Estrogen sensitive cancers include uterine, ovarian, cervical, prostate, and even head and neck cancers. According to the American Cancer Society, an estimated 207,090 new cases of invasive breast cancer are expected to occur among women in the US during 2010; about 1,970 new cases are expected in men. Avoid chances of becoming a statistic and assess estrogen levels and decrease risk with the Estronex Profile.
0142 – Estronex Profile
0145 – Estronex Profile with Bone Resorption
The Estronex Profile with Bone Resorption measures six important estrogen metabolites, as well as current bone loss. Assessment includes:
Deoxypyridinoline – a fragment of Type I collagen breakdown that contains the cross-linking point and has been demonstrated to be more specific to bone resorption than breakdown fragments measured in some earlier assays.
0145 – Estronex Profile with Bone Resorption
Food allergy is a common problem in children and adults. Many patients present with adverse reactions to foods, but are not diagnosed with ‘allergies’ by routine methods. To date, the traditional diagnosis of food allergy is based on clinical history, skin-prick tests, the determination of specific IgE class antibodies from serum, and the gold standard ‘food challenge’, which is both cumbersome and problematic to perform. It is now known that the underlying mechanisms for allergy are not restricted to IgE-mediated reactions alone, but that there are many different mechanisms that can give rise to these allergy symptoms. There is therefore a marked discrepancy between those displaying allergy reactions, and those with traditionally diagnosed food allergy. This advanced allergy assay provides a powerful tool for the detection of adverse reaction to food and additives. By measuring the cellular reaction to food allergens, both IgE mediated and non-IgE mediated reactions can be reliably detected.
This profile measures reactions to commonly found food additives and preservatives. Food additives are capable of inducing pseudoallergic reactions similar to aspirin and NSAIDâ¿¿s. These reactions often imitate IgE mediated immediate type reactions. The exact mechanisms of these reactions are still not clearly understood. The most accepted hypothesis describes the reaction as a non-immunological activation of inflammatory cells like mast cells, basophils and others. Cellular analysis represents a proven technology for the detection of such reactions.
This profile measures reactions to commonly used antibiotics and analgesics. Hypersensitivity to aspirin and other non-steroidal anti-inflammatory drugs is a well recognized condition and has attracted increasing attention in the last four decades. This syndrome presents either in the airways as recurrent rhinitis and followed by asthma attacks, or by skin manifestations such as urticaria and angioedema. Allergic reactions to antibiotics are the most common cause of adverse drug reactions mediated by specific immunological mechanisms. Determination of specific IgE, although indicative, often has a limited diagnostic value, since drug-specific serum IgE usually decreases or disappears within weeks or months after the last exposure. A number of well-controlled and validated studies have clearly shown that ASA/NSAID and antibiotics can induce sLT release and degranulation of basophils detected by cellular analysis.
This test measures sensitivities against all cow, sheep, goat, and soya products as well as all grains and yeast. A marker called tissue transglutaminase (tTGA), which is highly specific at identifying untreated Coeliac Disease, is also measured.
This combined panel assesses food intolerances and inhalant allergies together. This is particularly useful for those with hay fever and/or sensitivities to nuts or fruits.
The Fat-Soluble Vitamins Profile is a great tool to gain an overall perspective of a patient’s health, nutrient processing, and dietary insufficiencies. Serum levels of the fat-soluble vitamins A, D, E, K plus beta-carotene and coenzyme Q10 are measured to evaluate total body status of these antioxidant nutrients.
Testing these nutrients together in one panel is important because nutrient functionality is dependent on the adequate supply of each nutrient. For bone health, taking vitamin D without adequate levels of vitamins A, E, and K may be detrimental since all are needed for proper bone calcification. Antioxidants, such as vitamin E, CoQ10, and beta-carotene, help ensure proper oxidation-reduction chain reactions.
0036 – Fat-Soluble Vitamins Profile – Serum
UPLC; EIA; Chemiluminescence
0041 – Fatty Acids (plus ratios)
GC/MS
0040 – Fatty Acids (plus ratios)
GC/MS
Ferritin is the most sensitive marker for an iron deficiency as it is the main storage form of iron in the body. This test measures serum levels.
This biochemistry analysis is a full haematology and biochemical assessment for Glucose & lipid metabolism, Renal Function, Adrenal Function, Liver Function, Thyroid & Parathyroid Function and Iron & Inflammation status.
The GI Effects Chemistries Profile focuses on proper gut function. This profile helps identify inflammatory and immune response, which is important since the gut makes up almost 80% of the body’s immune system. Short chain fatty acids (SCFAs), inflammation, immunology, red blood cells, as well as digestion and absorption abilities are the focus of this GI profile.
The GI Effects Chemistries Profile is an affordable follow-up test to help practitioners monitor targeted patient therapy. It also requires only one sample collection leading to improved patient compliance.
2120 – Chemistry Profile – Digestive, inflammation, absorption
Method: GC/MS, HPLC, EIA, Automated Chemistry, Colorimetric
The GI Effects Comprehensive Profile is unlike any other stool analysis profile, going beyond the standard parameters for identifying gastrointestinal disorders.
Video: Introducing the GI Effects 2200
The GI Effects Comprehensive Profile uses the best of both culture-based and molecular approaches for stool-based gastrointestinal diagnostics. O&P technology can identify an unlimited number of parasites and is the gold standard diagnostic methodology for parasite detection, while PCR technology provides an expansive assessment of anaerobic gut microflora.
Gastrointestinal function is important for general health. The intestinal tract contains significant amounts of bacteria which, when imbalanced, have been associated with IBS and IBD, immune disorders, diabetes, and cardiovascular disease. Balancing gut microflora is key for optimizing digestion and absorption of nutrients, as well as metabolic functions. Poor digestion and malabsorption can lead to immune dysfunction, nutritional insufficiencies, mental/emotional disorders, and autoimmune diseases.
GI Effects 2200: Comprehensive Profile (Includes 2205, 2110, and 2120)
Method: Microscopic examination, Macroscopic evaluation, EIA, PCR, GC/MS, HPLC, Automated Chemistry, Colorimetric
Pathogens (C. difficile, H. pylori, Shiga Toxin E. coli, and Campylobacter spp) (Available as EIA add-ons)
The GI Effects Microbial Ecology Profile uses DNA analysis to identify microbiota including anaerobes, a previously immeasurable area of the gut environment. DNA assessment is highly accurate and reports results as specific numbers.
Over 99% of the bacteria in the gut are anaerobes, but in the cecum, aerobic bacteria reach high densities. Under normal homeostatic conditions, the intestinal microflora are of central importance in preventing colonization by pathogens, termed “colonization resistance.” Microorganisms perform a host of useful functions, such as fermenting unused energy substrates, communicating with the immune system, preventing growth of harmful species, regulating the development of the gut, producing vitamins for the host (such as biotin and vitamin K), and producing hormones.
The Microbial Profile focuses on predominate, opportunistic, and pathogenic bacteria, as well as yeast/fungi, parasites, adiposity index, and microbial and fungi sensitivities. The Microbial Profile is also an easy and cost-effective follow-up testing option to monitor targeted therapy in patients.
2205 – Microbial Profile – Bacteria, fungi/yeast, parasites
Product Line: GI / Immunology
Method : PCR
Pathogens (C. difficile, H. pylori, Shiga Toxin E. coli, and Campylobacter spp) (Available as EIA add-ons)
The GI Effects Profile uses DNA analysis to identify microbiota including anaerobes, a previously immeasurable area of the gut environment. DNA assessment is highly accurate and reports results as specific numbers.
The Mycology Profile is also an easy and cost-effective follow-up testing option to monitor targeted therapy in patients for yeast/fungi overgrowth.
Yeast in small amounts is considered normal. However, yeast overgrowth in the gut has been linked to many chronic conditions, in part because of antigenic responses in some patients to even low rates of yeast growth. Potential symptoms can include diarrhea, headache, bloating, atopic dermatitis, and fatigue. The GI Effects Mycology Profile identifies yeast and fungi, in real quantitative amounts, as well as fungal sensitivities of pharmaceuticals and botanicals.
2110 – Mycology Profile – Fungi/yeast only
Method: PCR
To assess gluten sensitivity, this profile offers a simple, salivary collection measuring anti-gliadin antibody (AGA) and secretory immunoglobulin A (sIgA). AGA measures the body’s response to gluten while SIgA defends against antigenic and infectious attacks at the mucosal surfaces.
0072 — Gliadin Sensitivity Profile
EIA
This test evaluates immunological imbalance specific to gastrointestinal tract inflammatory disease activity specific to the gastrointestinal tract. A simple, reliable and non-invsive test, the GI profile measure calprotectin and Eosinophil protein X. Increased levels of EPX have been found in ulcerative colitis and Crohn’s disease, with elevations correlating with disease activity.
Helicobacter pylori is believed to be the only bacteria able to withstand the acidity of the stomach and has been shown to be the single biggest cause of gastric and duodenal ulcers and gastritis. It is now believed that virtually all-abdominal ulcers, apart from drug-induced forms, are caused by a Helicobacter pylori infection. The breath procedure is a highly accurate and non-invasive diagnostic tool utilising a C13 powder to detect the presence of an active H.pylori infection.
Helicobacter pylori is a bacterial infection strongly associated with persistent stomach inflammation. Such inflammation can significantly increase the risk of stomach or duodenal ulcer formation. The stool test is a convenient, non-invasive way of testing for H.pylori for both diagnosis and follow-up testing. This marker can also be added to other larger stool tests by request.
Total plasma homocysteine levels are widely implicated in a variety of clinical conditions and are an independent risk factor for cardiovascular, atherothrombotic and cerebrovascular disease. Certain key nutrients, including Vitamin B12, Vitamin B6 and folic acid, are necessary for homocysteine metabolism; therefore this test can also provide valuable information about a patient’s nutritional status relating to these nutrients.
This test provides a focused overview of hormonal balance in both pre- and post-menopausal women, using serum to evaluate the dynamics of sex steroid metabolism that can profoundly affect a woman’s health throughout her lifetime.
IBStatus offers a concise look at the overall health of the gastrointestinal (GI) tract. It is a non-invasive evaluation that uses biotechnology to evaluate digestion, absorption, inflammation, and parasite infection. This test is designed to specifically help identify inflammatory conditions (including subclinical inflammation) associated with Inflammatory Bowel Disease (IBD), NSAID enteropathy, and post-infectious Irritable Bowel Syndrome (IBS).
The ION (Individual•Optimal•Nutrition) Profile is a combination of analyses that measures levels of organic acids, fatty acids, amino acids, vitamins, minerals, and antioxidants, offering a complete evaluation of functions that impact patients’ mental and physical well-being.
Over time, functional nutritional inadequacies can result in a variety of chronic health conditions. The ION Profile can help determine the basis for these conditions.
Heart Disease: where deficiencies of magnesium, taurine, carnitine, fatty acids and other important substances commonly accompany heart disease. Re-supplying depleted nutrients greatly aids in prevention and recovery.
Obesity and Weight Issues: many obese persons have multiple nutritional deficiencies. Dietary improvement and nutritional supplementation based on ION test results help many achieve more active metabolism. In the process, they are able to eliminate excess fat and fluid.
Chronic Fatigue Syndrome: an enigmatic disorder that frequently involves mitochondrial inefficiencies (deficits in cellular energy production) that can be revealed by comparing the organic acids, amino acids and minerals test results.
Immune System Disorders: where deficiencies in a wide variety of nutrients, from amino acids to fatty acids to zinc, are seen.
Developmental Delays: increasing numbers of children are experiencing dramatic improvements in development and achievement due to supplementation based on ION test results.
Mood Disorders: often have underlying biochemical imbalances which are revealed by testing for organic acids, amino acids, minerals, and fatty acids.
Multiple Chemical Sensitivities: functional nutrient levels are affected, including many of those involved in cellular respiration. The ION profile can determine where imbalances occur.
0090 – ION™ Profile
0068 – Chemistries
0490 – ION Profile w/Amino Acids 40
Method: 0090: LC/MS-MS, HPLC, UPLC, ICP/MS, GC/MS, Spectrophotometry, Chemiluminescence 0068: Spectrophotometry, Automated Chemistry
Panels consisting of 10 foods can be created to suit the individual and will be tested for acute IgE allergies. Please contact the laboratory to discuss these further.
Panels consisting of either 5 foods can be created to suit the individual and will be tested for acute IgE allergies. Please contact the laboratory to discuss these further.
This test measures levels of specific IgE antibodies for acute classical allergies, against 37 common foods. Symptoms usually present immediately and include hayfever, asthma, urticaria, swollen/itchy throat, tongue, lips, gums, watery/itchy/swollen eyes, rhinitis, colic, anaphylaxis, eczema, and skin rashes.
This panel identifies classical (IgE) inhalant allergies to 27 of the most common airborne allergens. Symptoms usually present immediately and include hayfever, asthma, urticaria, watery/itchy/swollen eyes, rhinitis, eczema, and skin rashes.
IgG antibodies are associated with ‘delayed’ or non-atopic food reactions that exacerbate or contribute to many different health problems. Simultaneous high levels of many IgG antibodies can also be associated with intestinal hyper permeability. This profile consists of 24 of the frequently used culinary herbs and spices that could otherwise be overlooked.
This test evaluates genetic variations in genes that modulate immune and inflammatory activity. These variations can affect balance between cell (Th-1) and humoral (Th-2) immunity, trigger potential defects in immune system defense, and stimulate mechanisms underlying chronic, overactive inflammatory responses. (Please note that genomic profiles are available through a registered practitioner only).
Individual IgE allergens are available on request. Please contact the laboratory to discuss these further.
Examination for adult cestodes, nematodes and trematodes or macroscopic worms or pieces of worms that may be shed in the stool.
The Male Hormonal Health™ is a hormonal test which provides a focused overview of hormonal balance in men.
This profile measures the hormones, cortisol, DHEA, testosterone and melatonin and allows for the detection of hormonal imbalances related to symptoms of male andropause, rapid ageing, low vitality and sexual dysfunction. Optimal health is dependent on the balance of these hormones, not just a single hormone.
Melatonin is a hormone that controls the daily circadian rhythm and is best known for its role in helping to initiate sleep. Imbalances can also include depression, Seasonal Affective Disorder (SAD), behavioural changes, mood disorders, and stress among others.
Menopause Profile is a non-invasive salivary/urine assessment that measures levels of progesterone, oestradiol, testosterone in addition to markers of bone turnover and oestrogen metabolism. Results can be used to identify imbalances contributing to menopausal symptoms as well as various systemic disorders and provides a valuable assessment of menopausal related conditions.
Menopause Plus is a comprehensive, non-invasive salivary/urine assay for the analysis of oestradiol, progesterone, testosterone and oestrogen metabolites as well as cortisol, DHEA, and melatonin. Results can be used to identify imbalances contributing to menopause symptoms and various systemic disorders, and to determine the need for hormone replacement therapy as well as the effect of stress hormones on sex hormones.
This profile measures stages of pre-diabetes and progression toward type 2 diabetes mellitus (T2DM) or Cardio-Metabolic Syndrome using metabolic, inflammatory, and lipid biomarkers.MetSyn Guide™ focuses on the importance of early assessment and correction of risk factors.
The Metabolic Analysis Profile (MAP) is an important clinical tool for treating imbalances underlying metabolic, nutritional, and neurological disorders. This test assesses four main Areas of metabolism: gastrointestinal function and dysbiosis markers, cellular energy production, neurotransmitter metabolites and an assessment of nutrient sufficiency. Using test results, practitioners can design comprehensive, customised therapies to restore optimal metabolic health.
Insulin resistance/insensitivity is closely linked with obesity, and occurs when the body stops being responsive to insulin. This leads to higher and higher levels of insulin being secreted by the pancreas in an attempt to maintain normal blood sugar levels. This profile measures other factors associated with ‘Metabolic Syndrome’ including hsCRP, insulin, cholesterol, triglycerides and glycosylated haemoglobin – a marker of long-term elevated blood glucose levels.
This test evaluates stool for levels of beneficial flora, imbalanced flora, and possible pathogens.
Neopterin and biopterin are by-products of the redox reactions involving tetrahydrobiopterin (BH4). BH4 functions as a cofactor for the enzymes responsible for the production of monoamine neurotransmitters (ephinepherine, norepinephrine, DOPA, serotonin), and as a cofactor in nitric oxide production. Low biopterin levels may reflect insufficient BH4 status. Restricted BH4 cofactor availability has been suggested as an etiologic factor in:
Neopterin is a marker of inflammation, allowing detection and monitoring of inflammatory processes. The origin of the inflammation may be the small intestine pathology that so often requires treatment in children with Autism Spectrum Disorders.
Neopterin is elevated in:
0088 – Neopterin/Biopterin Profile
LC/MS-MS, Spectrophotometry
This test evaluates single nucleotide polymorphisms (SNPs) in genes that modulate methylation, glutathione conjugation, oxidative protection and the potential to evaluate vascular oxidation.
Unlike any other nutritional assessments, NutrEval® provides a framework of core nutrients in 5 key areas: Antioxidants, B Vitamins, Digestive Support, Essential Fatty Acids, and Minerals. The Amino Acids are measured in a convenient first-morning urine collection. The NutrEval Plus also includes the FACTest™: a cellular food allergy assessment, covering both IgE mediated and non-IgE mediated inflammatory reactions.
Unlike any other nutritional assessments, NutrEval® provides a framework of core nutrients in 5 key areas: Antioxidants, B Vitamins, Digestive Support, Essential Fatty Acids, and Minerals. The Amino Acids are measured in a convenient first-morning urine collection.
Erythrocyte and whole blood toxic element levels are good indicators of body pools of essential elements as well as the toxic elements aluminum, arsenic, cadmium, lead, and mercury. TheGenova Diagnostics Nutrient and Toxic Elements Profile is an especially accurate way of determining whole body status of potassium and selenium.
Whole Blood generally reflects increased or recent exposure to toxic elements. The Genova Diagnostics Toxic Metals Profileshows levels of cadmium, lead, and mercury.
Nutrient elements are measured in erythrocytes and toxic elements are measured in whole blood. One exception is selenium, which is measured in whole blood as a reliable index of selenium status.
0022 – Nutrient and Toxic Elements
The ONE FMV® will help you understand your patients’ individual diet and supplementation needs. By assessing organic acids and amino acids, this panel offers personalised functional nutrition assessments covering Antioxidants, B Vitamins, Digestive Support, and Minerals.
This urine test measures 2-hydroxy and 16-alpha-hydroxy oestrogens, providing a convenient way of evaluating clinical interventions aimed at optimising oestrogen metabolism.
This test provides a comprehensive analysis of urinary oestrogen metabolites that correlate with breast and prostate cancer risk, including 2-hydroxy, 4-hydroxy and 16-alpha-hydroxy oestrogens, and their methylated byproducts. This provides valuable information about oestrogen-related diseases, such as breast cancer and prostate disease risk.
The Organix Profile provides a view into the body’s cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic Blocks that can be treated nutritionally allows individual tailoring of interventions to help maximize patient responses and lead to improved patient outcomes.
Organic acids are metabolic intermediates produced in pathways of central energy production, detoxification, neurotransmitter breakdown, and intestinal microbial activity. Accumulation of specific organic acids in urine often signals a metabolic inhibition or block. This abnormality may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect. An organic acids urine test helps reveal activity and changes at the metabolic level, helping practitioners discover hidden issues and pinpoint where therapeutic focus is needed.
0291 – Organix Basic Profile
LC/MS-MS Tandem Mass Spectrometry
The Organix Comprehensive Profile provides a view into the body’s cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic Blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes. Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. Several of the analytes are markers of intestinal bacterial or yeast overgrowth.
0091 – Organix Comprehensive Profile
LC/MS-MS Tandem Mass Spectrometry
The Russian scientist Elie Metchnikoff (1845 – 1916) popularized the idea of “Dys-symbiosis” or “Dysbiosis,” describing an imbalance in the microecology of the digestive tract. When the microbial balance of the gut is disturbed, opportunistic, or “bad”, bacteria can overgrow and mitigate the effects of the “good”, predominant bacteria needed for a healthy gut.
The Organix Dysbiosis Profile is a urine organic acid test measuring the by-products of microbial metabolism, and is particularly useful in detecting the presence of pathogenic microbial overgrowth. As a stand-alone test, the Organix Dysbiosis Profile is a great follow-up option to the Organix Comprehensive Profile, allowing the clinician to assess microbial overgrowth and guide and monitor targeted therapy in patients.
Urine contains unique products of microbial metabolism which are used to measure small bowel yeast and bacterial overgrowth. With the exception of hippurate, the compounds measured in the Organix Dysbiosis Profile, such as D-arabinitol, are not normally produced by human cells. Unfriendly intestinal microorganisms, however, can manufacture them in relatively high quantities. These compounds are absorbed into the blood from the intestines and eventually appear in a urine organic acid test.
Stool testing also gives insight into the gut microbial population of the large bowel.
The Organix Dysbiosis Profile and the GI Effects Stool Profile can be utilized together to gain an overall snapshot of a patient’s gut health.
0097 – Organix Dysbiosis Profile
LC/MS-MS Tandem Mass Spectrometry
This test utilises a blood sample in order to evaluate the body’s oxidative stress status and antioxidant reserve. This test can help practitioners identify underlying causes and perpetuating factors for many clinical disorders.
This test utilises a urine sample in order to evaluate the body’s oxidative stress status and antoxidant reserve. It can help practitioners identify underlying causes and perpetuating factors for many clinical disorders.
This test evaluates stool for the presence of parasites, using microscopic examination only. This is an ideal test for a follow-up after addressing an initial discovery of parasites.
This profile measures stages of pre-diabetes and progression toward type 2 diabetes mellitus (T2DM) using metabolic and inflammatory biomarkers. PreD Guide™ focuses on the importance of early assessment and correction of risk factors.
Under certain conditions, the conversion of T4 to T3 can be impaired, resulting in high levels of reverse t3 (rT3). Although chemically similar to T3, reverse T3 is completely inactive and lowers the amount of active thyroid hormone available to the cells. A selenium deficiency, excess physical, mental and environmental stresses can all inhibit the deiodinating enzyme which is responsible for this conversion. This can be termed ‘sick euthyroid’ or ‘low T3 syndrome’. Reverse T3 can be included in the Total Thyroid Screen on request.
As well as assessing the monthly fluctuations in Oestradiol and Progesterone through the female hormone panel, this panel also assesses Melatonin and the Adrenal Hormones, Cortisol and DHEA.
This 12-sample saliva test measures progesterone, oestrogen and testosterone levels over the monthly cycle to identify any hormonal imbalances. Common symptoms of this can include premenstrual tension, fluid retention, excessive menstrual bleeding, menstrual irregularity, low libido, endometriosis, ovarian cysts, infertility, acne, and excess body hair
SIgA is an important indicator of digestive immune function. Chronic intestinal infections (due to bacterial, yeast or parasites), food sensitivities, aging, antibiotics, medication and stress all decrease sIgA levels. Low levels can lead to recurrent infections and food intolerances. Very low levels of this important antibody class have also been observed in autistic spectrum disorders.
Tissue transglutaminase has been proven to be highly specific in detecting untreated Coeliac Disease and is the target antibody in this disease.
The TRIAD Bloodspot Profile gives your patients an easy-to-use option to collect their specimens at home – no blood draw required! With simple finger sticks and an overnight urine collection, the TRIAD Bloodspot Profile gives you the same quantitative information as the TRIAD Profile.
Using the synergetic power of the Organix, Amino Acids, andAllergix IgG4 Food Antibodies testing, faster and more effective results are produced. Because targeted, individualized interventions based on the TRIAD Bloodspot Profile can be more cost-effective than simple protocol-based treatment plans, the TRIAD Bloodspot Profile represents real value.
The TRIAD Bloodspot Profile includes fully customized intervention guidelines (custom vitamin/mineral formulas, custom amino acid blends, and an online food reaction guide) so you can focus your interventions on the specific needs of each patient.
0400 – TRIAD™ Profile
Method: LC/MS-MS, HPLC, Spectrophotometry, EIA
The TRIAD Profile helps you target each patient’s specific needs by integrating three powerful profiles (Organix, Amino Acids, and Allergix IgG Food Antibodies) into a single innovative tool offering customized intervention options.
Patients with similar symptoms can have remarkably different metabolic and nutritional needs. And patients with comparable laboratory results often exhibit widely divergent symptoms.
The logic behind the TRIAD Profile is simple. Clinicians, like you, told us that interventions based on Organix, Amino Acid, or Allergix IgG Food Antibodies testing produced excellent results. The TRIAD Profile uses the synergetic power of these three components to produce better results, faster. Because targeted, customized interventions based on the TRIAD Profile can be more cost effective than simple protocol-based treatment plans, the TRIAD Profile represents real value.
Only the TRIAD Profile includes fully customized intervention guidelines (custom vitamin/mineral formulas, custom amino acid blends, and a customized food rotation diet) so you can focus your interventions on the specific needs of each patient.
0400 – TRIAD™ Profile
Method: LC/MS-MS, HPLC, Spectrophotometry, EIA
This test measures salivary testosterone levels, the principal androgen in men, and can allow for the detection of hormonal imbalances related to symptoms of male andropause, as well as those related to imbalanced testosterone commonly found in women. This test can be used to assess baseline levels and monitor testosterone replacement therapy.
This test is a more cost effective way of combining the Total Thyroid Screen with Reverse T3 to give the full picture of thyroid health status. Thyroid imbalances have far reaching effects and elicit fatigue, depression, coldness, constipation, poor skin, headaches, PMS, dysmenorrhea, fluid retention, weight gain, anxiety/panic attacks, decreased memory and concentration, muscle and joint pain, and a low sex drive.
This test analyses serum levels of TSH, total T4, free T4, free T3, anti-TG antibodies, and anti-TPO antibodies to assess central and peripheral thyroid function, as well as thyroid auto-immunity.
This test measures urinary excretion of toxic metals, including ‘classic’ toxics such as lead, mercury, and arsenic. This is an ideal test for patients suspected of toxic element exposure.
Whole Blood generally reflects Increased or recent exposure to toxic elements. The Genova DiagnosticsToxic Metals Profileshows levels of aluminum, arsenic, cadmium, lead, and mercury.
0026 – Toxic Metals
Increased exposure to toxic elements is generally reflected by levels in whole blood. This test shows levels of aluminum, arsenic, cadmium, lead, and mercury.
Found in leafy green vegetables, natural folates are the group name for related members of this B-vitamin family. A synthetic form, folic acid (FA), is used in fortified foods and most dietary supplements. In fact, looking to combat birth defects such as cleft palates and spina bifida, the U.S. government began mandating the use of synthetic FA to fortify the national food supply in 1988. However, new research indicates that the increased intake of synthetic FA, combined with the slow and variable effects produced by the enzyme Dihydrofolate Reductase (DHFR), can lead to an accumulation of Unmetabolized Folic Acid (UMFA) in the blood.
0030 — Unmetabolized Folic Acid – Serum
LC/MS/MS
Iodine is an essential trace element, vital for healthy thyroid function. Adequate levels are required to enable the production of T3 and T4 thyroid hormones, whilst also being required in other Areas of health. Deficiencies can lead to impaired heat and energy production, mental function and slow metabolism. Urine iodine is one of the best measures of iodine status. This test is not performed as a loading test, but can be used to establish existing levels or to monitor iodine supplementation.
The elevation of thyroid hormone levels in urine, assesses tissue exposure to thyroid hormones over a 24-hour period. The urine thyroid test therefore serves as a valuable tool for detecting those patients that are suffering from thyroid dysfunction, particularly low grade hypothyroidism who might otherwise go undetected through standard blood tests. It is important to use this test as an adjunct to other indicators of thyroid function, such as body temperature, symptomology and standard blood thyroid tests.
A cost effective method of combining the urine thyroid hormone test (T3 &T4 only) with urinary iodine. Iodine is vital for optimal thyroid health and deficienies are often implicated in hypothyroidism.
Evaluates vaginal bacteria, yeast, cytolysis, leukocytes, RBCs and Trichomonas.
The analysis of these important vitamins is part of an assessment of certain types of anaemia and nutrient status during pregnancy.
Vitamin D has a hormone like effect, which has a high prevalence of deficiency and insufficiency, even in normal populations. There is growing evidence that vitamin D is involved in an increasing number of chronic diseases including bone disease, cancer, autoimmune disease, cardiovascular disease, chronic fatigue and mental health problems.
Vitamin K is a fat-soluble vitamin that functions as a cofactor in the production of blood coagulation factors (in the liver), osteocalcin (in bone), and matrix Gla-proteins (in cartilage and vessel walls), each resulting in the deposition of ionic calcium.
Monitoring vitamin K can help reduce risk of osteoporotic bone fractures, cardiovascular disease, and possibly some cancers by identifying individuals who may have a vitamin K deficiency. Since current dietary recommendations of vitamin K are based on saturation of the coagulation system, those recommendations may be insufficient to maintain vascular and bone health, since individual functions are independent of each other.
Direct vs. functional measurement of vitamin K
The Metametrix Vitamin K Assay measures a functional marker, undercarboxylated osteocalcin (ucOC). Very little vitamin K is stored in the body therefore direct measurement is not ideal.
Osteocalcin (OC) is almost exclusively a product of mature, active osteoblasts and is a vitamin K-dependent, Ca+2 binding protein. A vitamin K deficiency is indicated by an ucOC increase in circulating blood and urine. Therefore, high ucOC indicates low vitamin K status.
There are two natural forms of vitamin K, which differ based on their phytyl group-phylloquinone (vitamin K1) synthesized from plants, and menaquinone (vitamin K2) from bacteria in the large intestines.
0031 — Vitamin K Assay
EIA
Understanding your health is necessary for optimal living. As with most other disease states, preventative care and the ability to predict what we are at risk for at the earliest stages is ideal in treating each individual.
The Women’s Health Profile can help assess those risk factors associated with genetics, biochemical imbalances, and environmental influences for women of all ages.
4146 – Women’s Health Profile
Method: EIA, Spectrophotometry, LC/MS/MS, HPLC, GC/MS, Automated Chemistry, Chemiluminescence, Colorimetric
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